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«Вестник анестезиологии и реаниматологии» Том 14, №3, 2017,

DOI : 10.21292/2078-5658-2017-14-3-51-57

Осталось ли место омега-3 жирным кислотам в кардиохирургии?

В. В. Ломиворотов 1 , С. М. Ефремов 1 , М. Н. Абубакиров 1 , Христиан Стоппе 2

  • 1 1ФГБУ «СФБМИЦ им. акад. Е. Н. Мешалкина» МЗ РФ, г. Новосибирск, Россия
  • 2 Клиника Рейнско-Вестфальского университета Ахена, Германия

Цель обзора: рассмотреть теоретические и прикладные аспекты применения омега-3 жирных кислот у кардиохирургических пациентов высокого риска с целью снижения выраженности системной воспалительной реакции, обусловленной применением искусственного кровообращения и лежащей в основе органных дисфункций в послеоперационном периоде.

Ключевые слова: омега-3 жирные кислоты, рыбий жир, нутритивная поддержка, синдром системной воспалительной реакции, искусственное кровообращение

Литература

  • 1. Ефремов С. М., Покушалов Е. А., Романов А. Б. и др. Исследование антиаритмических эффектов полиненасыщенных жирных кислот в кардиохирургии. Данные имплантируемого монитора ритма сердца // Патология кровообращения и кардиохирургия. − 2014. – Т. 18, № 3. – С. 12−18.
  • 2. Филипповская Ж. С., Герасименко О. Н., Гребенчиков О. А. и др. Оксидантный стресс и ранние осложнения послеоперационного периода в кардиохирургии // Вестн. анестезиол. и реаниматол. − 2016. – Т. 13, № 6. – С. 13−21.
  • 3. Arterburn L. M., Hall E. B., Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans // Am. J. Clin. nutrition. − 2006. – Vol. 83 (6 Suppl.). − P. 1467S−1476S.
  • 4. Bang H. O., Dyerberg J., Hjoorne N. The composition of food consumed by Greenland Eskimos // Acta Med. Scandinavica. – 1976. – Vol. 200, № 1−2. – P. 69−73.
  • 5. Bays H. E. Safety considerations with omega-3 fatty acid therapy // Am. J. Cardiol. – 2007. – Vol. 99. – P. 35−43.
  • 6. Benjamin E. J., Blaha M. J., Chiuve S. E. On behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2017 update: a report from the American Heart Association // Circulation. – doi: 10.1161/CIR.0000000000000485
  • 7. Calò L., Bianconi L., Colivicchi F. et al. N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial // J. Am. Coll Cardiol. – 2005. – Vol. 17, № 45. – P. 1723−1728.
  • 8. Carpentier Y. A., Dupont I. E. Advances in intravenous lipid emulsions // World J. Surg. – 2000. – Vol. 24. – P. 1493–1497.
  • 9. Charman A., Muriithi E. W., Milne E. et al. Fish oil before cardiac surgery: neutrophil activation is unaffected but myocardial damage is moderated // Prostaglandins Leukot Essent Fatty Acids. – 2005. – Vol. 72, № 4. – P. 257−265.
  • 10. Daren K. H., Lukan J. K., McClave S. A. The role of nutritional support in sepsis // Springer US, The Sepsis Text. – 2002. – P. 479−490, ISBN 978-0-306-47664-8.
  • 11. Duvall M. G., Levy B. D. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation // Eur. J. Pharmacol. – 2016. – Vol. 15, № 785. – P. 144−155.
  • 12. Friedman A., Moe S. Review of the effects of omega-3 supplementation in dialysis patients // Clin. J. Am. Society Nephrology. – 2006. – Vol. 1. – P. 182–192.
  • 13. Harris W. S. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? // Am. J. Cardiol. – 2007. – Vol. 19, № 99. – P. 44C−46C.
  • 14. Kantarci A., Van Dyke T. E. Lipoxins in chronic inflammation // Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists. – 2003. – Vol. 14, № 1. – P. 4.
  • 15. Klek S., Kulig J., Sierzega M. et al. The impact of immunostimulating nutrition on infectious complications after upper gastrointestinal surgery: a prospective, randomized, clinical trial // Ann. Surgery. – 2008. – Vol. 248, № 2. – P. 212−220.
  • 16. Kloner R. A., Jennings R. B. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1 // Circulation. – 2001. – Vol. 104, № 24. – P. 2981−2989.
  • 17. Koster S., Oosterveld F. G., Hensens A. G. et al. Delirium after cardiac surgery and predictive validity of a risk checklist // Ann. Thoracic Surgery. – 2008. – Vol. 86, № 6. – P. 1883−1887.
  • 18. Laffey J. G., Boylan J. F., Cheng D. C. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist // Anesthesiology. – 2002. – Vol. 97, № 1. – P. 215−252.
  • 19. Li X. L., Steiner M. Fish oil: a potent inhibitor of platelet adhesiveness // Blood. – 1990. – Vol. 76. – P. 938−945.
  • 20. Marchioli R., Barzi F., Bomba E. et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione // Circulation. – 2002. – Vol. 105. – P. 1897–1903.
  • 21. Mariani J., Doval H. C., Nul D. et al. N-3 polyunsaturated fatty acids to prevent atrial fibrillation: updated systematic review and meta-analysis of randomized controlled trials // J. Am. Heart Association. – 2013. – Vol. 2, № 1. – e005033.
  • 22. Manzanares W., Langlois P. L., Dhaliwal R. et al. Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis // Crit. Care. – 2015. – Vol. 19. – P. 167.
  • 23. Mayer K., Gokorsch S., Fegbeutel C. et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis // Am. J. Respire. Crit. Care Med. – 2003. – Vol. 167, № 10. – P. 1321−1328.
  • 24. McGowan F. X., Ikegami M., Nido P. J. et al. Cardiopulmonary bypass significantly reduces surfactant activity in children // J. Thorac. Cardiovasc. Surg. – Vol. 106, № 1993. – P. 968–977.
  • 25. Montgomery P., Richardson A. J. Omega-3 fatty acids for bipolar disorder // Cochrane database of systematic reviews. – 2008. – Vol. 2. – CD005169.
  • 26. Mozaffarian D., Marchioli R., Gardner T. et al. The ω-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) trial-rationale and design // Am. Heart J. – 2011. – Vol. 162, № 1. – P. 56−63.
  • 27. Mozaffarian D., Wu J. H. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events // J. Am. College Cardiology. – 2011. – Vol. 58, № 20. – P. 2047−2067.
  • 28. Ott J., Hiesgen C., Mayer K. Lipids in critical care medicine // Prostaglandins, leukotrienes, and essential fatty acids. – 2011. – Vol. 85, № 5. – P. 267−273.
  • 29. Ovize M., Baxter G. F., Di Lisa F. et al. Postconditioning and protection from reperfusion injury: where do we stand? // Cardiovasc. Res. – 2010. – Vol. 87. – P. 406−423.
  • 30. Parish M., Valiyi F., Hamishehkar H. et al. The effect of Omega-3 fatty acids on ARDS: A Randomized Double-Blind Study // Advanced Pharmaceutical Bulletin. – 2014. – Vol. 4, Suppl. 2. – P. 555−561.
  • 31. Pascal L., Langlois G. H., Manzanares W. ω-3 polyunsaturated fatty acids in cardiac surgery patients // J. Parenteral and Enteral Nutrition. – Vol. 41, Issue 2. – P. 152–154.
  • 32. Pennock J., Pierce W., Waldhausen J. The management of the lungs during cardiopulmonary bypass // Surg. Gynecol Obstet. – 1977. – Vol. 145. – P. 917–927.
  • 33. Pontes-Arruda A., Martins L. F., de Lima S. M. et al. Investigating nutritional therapy with EPA, GLA and antioxidants role in sepsis treatment (INTERSEPT) Study Group. Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study // Crit. Care. – 2011. – Vol. 9, № 15. – P. R144.
  • 34. Plourde M., Cunnane S. C. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements // Applied physiology, nutrition, and metabolism // Physiologie appliquee, nutrition et metabolisme. – 2007. – Vol. 32, № 4. – P. 619−634.
  • 35. Rees A. M., Austin M. P., Parker G. B. Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial // The Austral. New Zealand J. Psychiatry. – 2008. – Vol. 42, № 3. – P. 199−205.
  • 36. Richard C. B., Smith J. E., Yeh Yu-Yan. The effects of dietary fish oil on alveolar type II cell fatty acids and lung surfactant phospholipids // Lipids March. – 1993. – Vol. 28, Is. 3. – P. 167–172.
  • 37. Rizos E. C., Ntzani E. E., Bika E. et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis // JAMA. – 2012. – Vol. 308, № 10. – P. 1024−1033.
  • 38. Roulet M., Frascarolo P., Pilet M. et al. Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma // JPEN J. Parenteral Enteral Nutrition. – 1997. – Vol. 21, № 5. – P. 296−301.
  • 39. Serhan C. N., Brain S. D., Buckley C. D. et al. Resolution of inflammation: state of the art, definitions and terms // FASEB journal: official publication of the Federation of American Societies for Experimental Biology. – 2007. – Vol. 21, № 2. – P. 325−332.
  • 40. Simoens C. M., Deckelbaum R. J., Massaut J. J. et al. Inclusion of 10% fish oil in mixed medium-chain triacylglycerol-long-chain triacylglycerol emulsions increases plasma triacylglycerol clearance and induces rapid eicosapentaenoic acid (20:5n-3) incorporation into blood cell phospholipids // Am. J. Clin. Nutrition. – 2008. – Vol. 88, № 2. – P. 282−288.
  • 41. Suleiman M. S., Zacharowski K., Angelini G. D. Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics // British J. Pharmacology. – 2008. – Vol. 153, № 1. – P. 21−33.
  • 42. Tsekos E., Reuter C., Stehle P. et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery // Clin. Nutrition. – 2004. – Vol. 23, № 3. – P. 325−330.
  • 43. Thomas C. H., Dilraj K. B., Dhya Al-Leswas et al. A randomized controlled trial investigating the effects of parenteral fish oil on survival outcomes in critically ill patients with sepsis // J. Parenteral and Enteral Nutrition. – Vol. 39, Issue 3. – P. 301–312.
  • 44. Wanten G. J., Calder P. C. Immune modulation by parenteral lipid emulsions // Am. J. Clin. Nutrition. – 2007. – Vol. 85, № 5. – P. 1171−1184.
  • 45. Yang G., Xue X., Chen Y. et al. Effects of cardiopulmonary bypass on lung nuclear factor-kappa B activity, cytokine release, and pulmonary function in dogs // Iranian J. Basic Med. Sciences. – 2015. – Vol. 18, № 12. – P. 1233−1242.

Для цитирования: Ломиворотов В. В., Ефремов С. М., Абубакиров М. Н., Стоппе Х. Осталось ли место омега-3 жирным кислотам в кардиохирургии? «Вестник анестезиологии и реаниматологии» 2017; 14(3):0.DOI : 10.21292/2078-5658-2017-14-3-51-57


Для цитирования: Ломиворотов В. В., Ефремов С. М., Абубакиров М. Н., Стоппе Х. Осталось ли место омега-3 жирным кислотам в кардиохирургии? «Вестник анестезиологии и реаниматологии» 2017; 14(3):0.DOI : 10.21292/2078-5658-2017-14-3-51-57

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